Inhibition of betanodavirus infection by inhibitors of endosomal acidification
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چکیده
منابع مشابه
Endosomal acidification inhibitors for the treatment of BRAF mutant tumors
Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells.
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Securin and separase modulate membrane traffic by affecting endosomal acidification.
Securin and separase play a key role in sister chromatid separation during anaphase. However, a growing body of evidence suggests that in addition to regulating chromosome segregation, securin and separase display functions implicated in membrane traffic in Caenorhabditis elegans and Drosophila. Here we show that in mammalian cells both securin and separase associate with membranes and that dep...
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ژورنال
عنوان ژورنال: Archives of Virology
سال: 2007
ISSN: 0304-8608,1432-8798
DOI: 10.1007/s00705-007-1061-7